1. A less negative resting membrane potential is made, leading to increased irritability. 2. Voltage-sensitive sodium channels become persistently active at the resting membrane potential . 3. This potassium conductance eventually drops and the cell returns to its resting membrane potential . 4. Lower potassium levels in the extracellular space cause hyperpolarization of the resting membrane potential . 5. In the heart, hypokalemia causes hyperpolarization in the myocytes'resting membrane potential . 6. This may allow Kv3.4-KCNE3 channels to contribute to setting resting membrane potential . 7. However, the removal of Na + does not alter the resting membrane potential of the cell. 8. In general, LTS cannot be triggered by depolarization of the neuron from the resting membrane potential . 9. They, along with the " leak " channels, establish the resting membrane potential of the cell. 10. Consequently, this shift in their activation profile results in channels that open closer to the resting membrane potential .
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